A quiet Saturday evening in Arizona quickly turned into a nationwide concern when 84-year-old Nancy Guthrie vanished from her Tucson home. For Today co-anchor Savannah Guthrie, February 2026 has become marked by a deeply personal crisis. What began as a missing persons case is now being investigated as a possible abduction, with troubling details emerging as of February 23.

Concern grew after Nancy failed to attend church the next morning, prompting a welfare check. Deputies discovered signs of forced entry and evidence of a struggle, including what authorities described as a blood trail near the front entrance. Pima County Sheriff Chris Nanos confirmed the home is being treated as a crime scene.

Nancy’s health conditions have heightened urgency. She relies on daily medication for serious cardiac issues, making it unlikely she could travel far on her own. Investigators are also examining a reported ransom note sent to a local news outlet containing specific details about Nancy and her residence. Savannah’s sister, Annie Guthrie, and her husband, Tommaso Cioni—who reportedly dropped Nancy home around 9:30 p.m. Saturday—have been seen publicly for the first time since the disappearance. Authorities say the family is fully cooperating.

Savannah has stepped away from Today and other professional commitments to be with her family. Federal agents have now joined the investigation, underscoring the case’s seriousness. As search efforts intensify, loved ones and the broader community remain hopeful for answers.